ESMC-600M-step1500k
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ESMC-600M-step250k
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View details ↗ESMC-600M-step500k
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View details ↗ESMC-600M-step750k
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View details ↗ESMC-6B
biohubESMC is a state-of-the-art protein language model that has learned the rules of protein biology from training on billions of protein sequences. ESMC provides representations of proteins enabling novel AI applications from therapeutic protein engineering to unlocking basic insights into protein biology across life. The ESMC 6B model has 6 billion parameters, with 80 layers and 2.37e23 training flops. We additionally release overtrained 300M and 600M parameter variants of ESMC for local inference and finetuning. The ESMFold2 structure prediction models are trained on top of a frozen ESMC 6B language model. ESMFold2 is a state-of-the-art model for protein structure prediction and design that defines a new frontier for speed and accuracy.
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View details ↗esmc-6b-2024-12
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View details ↗ESMC-6B-hf
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View details ↗ESMC-6B-step1000k
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View details ↗ESMC-6B-step250k
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View details ↗ESMC-6B-step500k
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View details ↗ESMC-6B-step750k
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View details ↗ESMFold2
biohubESMFold2 is a state-of-the-art model for protein structure prediction and design that defines a new frontier for speed and accuracy. The model predicts high-resolution, all-atom 3D protein structures directly from amino acid sequences, with optional multiple sequence alignment (MSA) input for enhanced accuracy on challenging targets. The model outputs comprehensive structural information including all-atom coordinates (backbone and side chains), confidence metrics (pLDDT, pAE, pTM, iPTM), and optional distogram predictions for detailed analysis of predicted structures. Unlike ESMFold, ESMFold2 is able to predict structures for all biomolecules, including small molecules, DNA, RNA, and modified amino acids. ESMFold2 is capable of either single-sequence or MSA conditioned structure prediction for improved accuracy on difficult targets. The ESMFold2-Fast variant is an inference optimized single-sequence structure prediction model and is not MSA conditioned. To run this model with the Biohub Platform API, visit the Biohub Platform.
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View details ↗ESMFold2-Experimental
biohubThe ESMFold2 Experimental Models are being released to support reproducibility of the findings in our paper, please refer to the paper and github for details. Please use ESMFold2 model for research work. ESMFold2 predicts high-resolution, all-atom 3D protein structures from either single-sequence or MSA conditioned structure prediction for improved accuracy on difficult targets.
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View details ↗The ESMFold2 Experimental Models are being released to support reproducibility of the findings in our paper, please refer to the paper and github for details. Please use ESMFold2 model for research work. ESMFold2 predicts high-resolution, all-atom 3D protein structures from either single-sequence or MSA conditioned structure prediction for improved accuracy on difficult targets.
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View details ↗The ESMFold2 Experimental Models are being released to support reproducibility of the findings in our paper, please refer to the paper and github for details. Please use ESMFold2 model for research work. ESMFold2 predicts high-resolution, all-atom 3D protein structures from either single-sequence or MSA conditioned structure prediction for improved accuracy on difficult targets.
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View details ↗基础档案已收录，详细介绍后续补充。可先查看厂商、分类与来源。
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View details ↗基础档案已收录，详细介绍后续补充。可先查看厂商、分类与来源。
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View details ↗The ESMFold2 Experimental Models are being released to support reproducibility of the findings in our paper, please refer to the paper and github for details. Please use ESMFold2 model for research work. ESMFold2 predicts high-resolution, all-atom 3D protein structures from either single-sequence or MSA conditioned structure prediction for improved accuracy on difficult targets.
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View details ↗ESMFold2-Fast
biohubESMFold2 is a state-of-the-art model for protein structure prediction and design that defines a new frontier for speed and accuracy. The model predicts high-resolution, all-atom 3D protein structures directly from amino acid sequences, with optional multiple sequence alignment (MSA) input for enhanced accuracy on challenging targets. The model outputs comprehensive structural information including all-atom coordinates (backbone and side chains), confidence metrics (pLDDT, pAE, pTM, iPTM), and optional distogram predictions for detailed analysis of predicted structures. Unlike ESMFold, ESMFold2 is able to predict structures for all biomolecules, including small molecules, DNA, RNA, and modified amino acids. ESMFold2 is capable of either single-sequence or MSA conditioned structure prediction for improved accuracy on difficult targets. The ESMFold2-Fast variant is an inference optimized single-sequence structure prediction model and is not MSA conditioned. To run this model with the Biohub Platform API, visit the Biohub Platform.
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View details ↗Qwen3.5-4B-heretic-gguf
Biomanticus> [!TIP] > **This model is reproducible!** > > See the README in the `reproduce` directory for more information. GPT-OSS-120B GPT-OSS-20B Qwen3-Next-80B-A3B-Thinking Qwen3-30BA3B-Thinking-2507 Qwen3.5-9B Qwen3.5-4B > [!Important] > Qwen3.5 models operate in thinking mode by default, generating thinking content signified by ` \n... \n\n` before producing the final responses. > To disable thinking content and obtain direct response, refer to the examples here. For streamlined integration, we recommend using Qwen3.5 via APIs. Below is a guide to use Qwen3.5 via OpenAI-compatible API. Qwen3.5 can be served via APIs with popular inference frameworks. In the following, we show example commands to launch OpenAI-Compatible API servers for Qwen3.5 models. > [!Important] > Inference efficiency and throughput vary significantly across frameworks. > We recommend using the latest framework versions to ensure optimal performance and compatibility. > For production workloads or high-throughput scenarios, dedicated serving engines such as SGLang, KTransformers or vLLM are strongly recommended. > [!Important] > The model has a default context length of 262,144 tokens. > If you encounter out-of-memory (OOM) errors, consider reducing the context window. > However, because Qwen3.5 leverages extended context for complex tasks, we advise maintaining a context length of at least 128K tokens to preserve thinking capabilities. SGLang is a fast serving framework for large language models and vision language models. SGLang from the main branch of the open-source repository is required for Qwen3.5, which can be installed using the following command in a fresh environment:
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View details ↗proteinglm-1b-mlm
biomap-research基础档案已收录，详细介绍后续补充。可先查看厂商、分类与来源。
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View details ↗BioMistral-7B
BioMistralLarge Language Models (LLMs) have demonstrated remarkable versatility in recent years, offering potential applications across specialized domains such as healthcare and medicine. Despite the availability of various open-source LLMs tailored for health contexts, adapting general-purpose LLMs to the medical domain presents significant challenges. In this paper, we introduce BioMistral, an open-source LLM tailored for the biomedical domain, utilizing Mistral as its foundation model and further pre-trained on PubMed Central. We conduct a comprehensive evaluation of BioMistral on a benchmark comprising 10 established medical question-answering (QA) tasks in English. We also explore lightweight models obtained through quantization and model merging approaches. Our results demonstrate BioMistral's superior performance compared to existing open-source medical models and its competitive edge against proprietary counterparts. Finally, to address the limited availability of data beyond English and to assess the multilingual generalization of medical LLMs, we automatically translated and evaluated this benchmark into 7 other languages. This marks the first large-scale multilingual evaluation of LLMs in the medical domain. Datasets, multilingual evaluation benchmarks, scripts, and all the models obtained during our experiments are freely released. **Advisory Notice!** Although BioMistral is intended to encapsulate medical knowledge sourced from high-quality evidence, it hasn't been tailored to effectively, safely, or suitably convey this knowledge within professional parameters for action. We advise refraining from utilizing BioMistral in medical contexts unless it undergoes thorough alignment with specific use cases and undergoes further testing, notably including randomized controlled trials in real-world medical environments. BioMistral 7B may possess inherent risks and biases that have not yet been thoroughly assessed. Additionally, the model's performance has not been evaluated in real-world clinical settings. Consequently, we recommend using BioMistral 7B strictly as a research tool and advise against deploying it in production environments for natural language generat
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View details ↗BioMistral-7B-DARE
BioMistral基础档案已收录，详细介绍后续补充。可先查看厂商、分类与来源。
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