Model overview
ESMFold2 is a state-of-the-art model for protein structure prediction and design that defines a new frontier for speed and accuracy. The model predicts high-resolution, all-atom 3D protein structures directly from amino acid sequences, with optional multiple sequence alignment (MSA) input for enhanced accuracy on challenging targets. The model outputs comprehensive structural information including all-atom coordinates (backbone and side chains), confidence metrics (pLDDT, pAE, pTM, iPTM), and optional distogram predictions for detailed analysis of predicted structures. Unlike ESMFold, ESMFold2 is able to predict structures for all biomolecules, including small molecules, DNA, RNA, and modified amino acids. ESMFold2 is capable of either single-sequence or MSA conditioned structure prediction for improved accuracy on difficult targets. The ESMFold2-Fast variant is an inference optimized single-sequence structure prediction model and is not MSA conditioned. To run this model with the Biohub Platform API, visit the Biohub Platform.
Key features
特点摘要待依据来源补齐，不凭模型名称推断能力。
Limitations & considerations
Sources are insufficient to establish specific limitations. Verify task performance, latency, data policies, licensing and version lifecycle.
Source prices & cost analysis
Prices vary by channel, region and configuration. Channel quotes are listed independently and are not treated as a single official provider price.
| Source / channel | Input | Output | Billing unit | Collected at |
|---|---|---|---|---|
| No verified prices yet. Check the source channel. | ||||
Estimate monthly base token costs
Estimates exclude cache discounts, tiered pricing, multimodal surcharges, web search, taxes and additional reasoning output.
Public benchmarks & run configuration
暂无已采集的可核验公开评分。模型未上榜不代表能力较低。
View full indexed rankings →Frequently asked questions
Do open weights permit free commercial use?
Not necessarily. Check the version license, commercial conditions and usage policies. Self-hosting incurs compute and maintenance costs.
Are these real-time billing prices?
These are timestamped source snapshots, not live billing prices. Check the channel for current versions, regions, discounts and billing methods.
Sources & traceability
许可证：mit。模型介绍与第三方评测均以原来源的具体版本和方法为准。