AI NEWS.cchyphaeon
**Ultra-fast neural inference of episodic positive selection in molecular sequences.** HyphAeon detects site-level episodic diversifying positive selection (dN/dS > 1) across arbitrary codon alignments and phylogenetic trees. It replaces numerical Maximum Likelihood Estimation with an axial geometric transformer using Continuous 4D Tree Rotary Position Embeddings (Tree-RoPE), reaching a 100x-1,000x speedup over HyPhy MEME and PAML CodeML while matching or exceeding their empirical statistical power at a strictly controlled false positive rate. - **Repository:** https://github.com/veg/HyphAeon - **Architecture notes:** ARCHITECTURE.md - **Developed by:** Sergei L. Kosakovsky Pond and collaborators - **License:** MIT
翻訳準備中のため原文を表示しています
**Ultra-fast neural inference of episodic positive selection in molecular sequences.** HyphAeon detects site-level episodic diversifying positive selection (dN/dS > 1) across arbitrary codon alignments and phylogenetic trees. It replaces numerical Maximum Likelihood Estimation with an axial geometric transformer using Continuous 4D Tree Rotary Position Embeddings (Tree-RoPE), reaching a 100x-1,000x speedup over HyPhy MEME and PAML CodeML while matching or exceeding their empirical statistical power at a strictly controlled false positive rate. - **Repository:** https://github.com/veg/HyphAeon - **Architecture notes:** ARCHITECTURE.md - **Developed by:** Sergei L. Kosakovsky Pond and collaborators - **License:** MIT